Bar honors Rep. Kerner REP. DAVE KERNER, D-Palm Springs, center, was recently recognized by Bar leaders for his ongoing advocacy for the preservation of the judicial branch as a co-equal branch of government and his help to adequately fund the judiciary. Also pictured is Bar President-elect Ramón Abadin, left, and President Greg Coleman, right. February 1, 2015 Regular News
Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scansUK health officials advise against antibiotics for acute sore throatNew guidance today from the United Kingdom’s National Institute for Health and Care Excellence (NICE) and Public Health England says general practitioners should not offer, and patients should not expect, antibiotics in most cases of acute sore throat.The recommendations, aimed at limiting antibiotic use and reducing antimicrobial resistance, explain that acute sore throat (including pharyngitis and tonsillitis) is often self-limiting, most frequently triggered by a viral infection of the upper respiratory tract, and that most people will get better within a week without antibiotics. They advise physicians to explain to patients the usual course of acute sore throat and to recommend tips for management of symptoms. They also advise patients to seek medical help if symptoms worsen rapidly or don’t improve after a week.The guidance also lays out criteria for physicians to use when evaluating patients with acute sore throat. It recommends that patients who score low on clinical criteria scoring systems (0 or 1 points on FeverPAIN or 0,1, or 2 on Centor) should not receive an antibiotic and should be advised to drink adequate fluids and consider pain relievers and medicated lozenges. Patients with FeverPAIN scores of 2 or 3 should be given a back-up antibiotic prescription if their symptoms don’t improve in 3 to 5 days. For patients most likely to benefit from an antibiotic (those with a FeverPAIN score or 4 or 5 or a Centor score of 3 or 4), the guidance calls for an immediate antibiotic, taking into account possible adverse effects and the unlikely event of complications if antibiotics are withheld.”We are living in a world where bacteria are becoming more resistant to antibiotics,” Gillian Leng, deputy chief executive at NICE, told the BBC. “It is vital these medicines are protected, and only used when they are effective.”Jan 26 NICE guidance on acute sore throatJan 26 BBC story Australian scientists find potential in a neglected class of antibioticsAustralian scientists report that a synthetic version of a neglected class of antibiotics showed efficacy against multidrug-resistant (MDR) bacteria in preclinical tests, according to a study today in Cell Chemical Biology.In the study, scientists from the University of Queensland identified the biosynthetic pathway of octapeptins, a family of lipopeptide antibiotics that were discovered nearly four decades ago and are structurally related to the last-resort antibiotic colistin. Octapeptins displayed activity against gram-negative bacteria in several studies but were ultimately neglected due to a proliferation of other antibiotics.In vitro testing against a panel of MDR bacteria revealed that one of the octapeptins identified, octapeptin C4, was more effective than colisitin against polymixin-resistant isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, but was not as effective against polymixin-resistant P aeruginosa in a mouse blood infection model, most likely due to high plasma protein binding. The scientists then designed a synthetic octapeptin with a similar structure to octapeptin C4 but reduced plasma protein binding that showed dramatically improved in vivo activity.”Our in vitro and in vivo efficacy data indicate the significant potential of novel octapeptin-like lipopeptides as new antibiotics against polymyxin-resistant Gram-negative superbugs,” the authors of the study write. They also note that octapeptins are potentially less toxic to the kidneys than colistin and polymixin BJan 26 Cell Chem Biol abstract Consumer group urges McDonald’s to detail an antibiotic-free-meat planAs part of the launch of a national campaign, the consumer and public health advocacy group US PIRG Education Fund is calling on McDonald’s Corp to commit to a specific timeline to phase out routine use of medically important antibiotics in its beef and pork supply chain, US PIRG (Public Interest Research Group) said in a news release yesterday.The organization is spotlighting McDonald’s because of its “outsized influence” as the largest US buyer of beef and has only a vague long-term antibiotics plan. Public health experts across the globe have warned that routine use of antibiotics in food animals helps spur antimicrobial resistance in a wide range of pathogens and poses a distinct threat to people.”Protecting antibiotics requires action, not reaction. If we don’t act now to preserve the effectiveness of these medicines, we’ll face a world in which common infections once again kill,” said Matthew Wellington, antibiotics program director for US PIRG Education Fund. “The Big Mac can make a big dent in stopping the misuse of antibiotics in our food system,” he added, referring to McDonald’s flagship hamburger.As part of its “Hold the Antibiotics” campaign launch, US PIRG has had nearly 10,000 people sign a petition to support its efforts. The group’s state affiliates also held events in front of McDonald’s franchises across the country to educate people about the perils of antibiotic-resistant bacteria and the important role that McDonald’s can play.In August 2017, McDonald’s announced that it will phase out use of highest-value human antibiotics in its global chicken supply, after having reached its US goal of serving broiler chickens raised without antibiotics in 2016. It has also signaled that it would take similar actions for its supply of beef, dairy cows, pork, and laying hens.Jan 25 US PIRG news releaseAug 24, 2017, CIDRAP News story “McDonald’s expands antibiotic-cutting steps globally” Officials in India announce world’s first drug-resistant typhoid outbreakOriginally published by CIDRAP News Jan 25In what is being called the world’s first outbreak of drug-resistant typhoid, more than 100 children are sick and dozens have died in Hyderabad, India, The News International, which is based in Pakistan, reported yesterday.”Typhoid cases resistant to third-generation antibiotic Ceftriaxone have been reported from different areas of Hyderabad, but so far we’re unable to find its source,” Health Services Sindh Director General Dr Muhammad Akhlaq Khan said.”Children in the age group of 2-10 years are being affected by this type of disease, but so far we don’t have any exact data on the deaths caused by this lethal disease.” Scientists at Aga Khan University (AKU) in Karachi, Pakistan, blamed the outbreak on contaminated water, but the Sindh Health Department has ruled that cause out, the story said.No official case count has been cited, but the city’s health department and local gastroenterologists have said more than 100 drug-resistant cases have been reported since November 2016, compared with only 6 cases from 2009 to 2014. The health department, in collaboration with AKU, has launched a mass vaccination campaign aimed at immunizing 250,000 children in the district.Typhoid is mainly caused by Salmonella enterica serotype Typhi bacteria. About 8 million people live in the Hyderabad metropolitan area.Jan 24 News International story Bowel disease, antibiotics tied to fecal transplant for recurrent C difficileOriginally published by CIDRAP News Jan 25A single-center study in Rhode Island found several risk factors, including inflammatory bowel disease and the use of metronidazole, for fecal microbiota transplantation (FMT) to address recurrent Clostridium difficile infection (CDI), according to a study yesterday in Infection Control and Hospital Epidemiology.The retrospective study compared 200 adults who underwent FMT for recurrent CDI to 75 patients who did not. The strongest risk factors for FMT for recurrent CDI were concomitant inflammatory bowel disease (P = .002), use of immunosuppressive therapy (P = .04), and use of metronidazole within 2 months before the first CDI (P = .02). The use of vancomycin for the first CDI was also a potential risk factor.The authors concluded, “This study provides important insights into the factors predictive for FMT in patients with recurrent CDI and highlights the potential racial and medical characteristics that affect the access of the patients to FMT.”Jan 24 Infect Control Hosp Epidemiol study Study finds reduced carbapenem consumption in French hospitalsOriginally published by CIDRAP News Jan 23Researchers in France report that a reduction in carbapenem consumption in French hospitals occurred after the release of national guidelines on carbapenem use in 2010, according to a study yesterday in Antimicrobial Resistance and Infection Control. They suggest that further carbapenem reduction could be linked to reduced use of fluoroquinolones and third-generation cephalosporins (3GCs).The ward-level multicenter retrospective study, which sought to determine factors associated with reduced carbapenem use in intensive care units (ICUs), medical wards, and surgical wards from 2009 through 2013, was based on data from French surveillance networks of antibiotics and multidrug-resistant bacteria in healthcare facilities. France released guidelines to limit the use of carbapenems in 2010, in response to a rise in carbapenemase-producing Enterobacteriaceae that’s been driven in part by a 145% increase in carbapenem use since 2000. The increase in carbapenem use was in response to the spread of extended-spectrum beta-lactamase–producing Enterobacteriaceae (ESBL-PE).A total of 493 wards from 259 healthcare facilities were included in the study (85 ICUs, 227 medical wards, and 181 surgical wards). Overall carbapenem consumption over the study period was equal to 73.4 defined daily doses per 1,000 patient days for ICUs, compared with 6.2 in medical wards and 5.4 in surgical wards. While the overall trend showed an increase in carbapenem use from 2009 through 2013 in all wards, the period following release of the guidelines (2011-2013) showed a 2.9% decrease in carbapenem use in ICUs and 1.6% decrease in medical wards. Carbapenem use continued to rise in surgical wards, but the annual growth rate declined from 17.8% to 2.7%.In multivariable analysis, factors associated with a higher probability of reducing carbapenem consumption included a geographic location in eastern France, a higher initial carbapenem-prescribing profile, and reductions in consumption of fluoroquinolones, glycopeptides, and piperacillin/tazobactam. A higher initial prescribing profile for 3GCs and location in high-risk regions for ESBL-PEs were associated with a lower probability of reducing carbapenem use. The authors note that this finding is explained by ESBL-PE risk, which is promoted by 3GC use and thus leads to more frequent carbapenem prescribing.The authors conclude, “Our study, carried out on a national scale, in a large number of hospital wards, suggests that a decrease in 3GC proportion in the overall antibiotic use, as well as the continuation of the reduction in fluoroquinolone use, could allow reducing ward-level carbapenem use.” Jan 22 Antimicrob Resist Infect Control study CARB-X seeks partners to support antibiotic developmentOriginally published by CIDRAP News Jan 23CARB-X, the public-private initiative that provides financial and technical support to companies in the early stages of antibiotic discovery and development, is looking to partner with additional accelerator organizations to support its pipeline of research projects.According to a press release today from CARB-X (the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator), the new accelerators are expected to provide a broad range of support to the 22 active research projects in the Powered by CARB-X portfolio. CARB-X says more projects will be added in the coming months.”Our accelerator partners are essential to CARB-X’s mission, providing guidance and expertise to help partner companies accelerate their research and deliver new life-saving antibiotics, vaccines, diagnostics, and other products to patients,” CARB-X Executive Director Kevin Outterson, JD, said in the press release.To date, CARB-X has awarded more than $60 million to help fund early research in new antibiotics, vaccines, and rapid diagnostics to treat drug-resistant infections. The organization is looking to partner with up to six additional accelerator partners in Europe, North America, and the rest of the world. Jan 23 CARB-X press release Single-center study finds low levels of C difficile transmission in kidsOriginally published by CIDRAP News Jan 23A single-center Clostridium difficile infection (CDI) study from Northwestern University in Chicago found transmission among symptomatic children uncommon, and they noted that investigation of shared healthcare exposures often did not identify a potential transmission source, according to a study today in Clinical Infectious Diseases.The investigators performed whole-genome sequencing on C difficile isolates collected from children diagnosed as having CDI from December 2012 to December 2013. Among 131 CDIs in 107 children, the authors identified 104 genetically distinct isolates. Of 84 CDIs occurring 8 weeks or longer after the start of the study, only 10 (11.9%) were caused by a strain similar to another isolate, which would indicate likely in-hospital transmission. The researchers identified shared healthcare facility exposures in only 7 of those 10 cases.The authors conclude, “C. difficile transmission among symptomatic children was very uncommon, and among putatively transmitted cases, investigation of shared healthcare exposures often did not identify a potential transmission source.”Jan 23 Clin Infect Dis abstract Deadly outbreak of resistant Acinetobacter frequently involved pneumoniaOriginally published by CIDRAP News Jan 23A separate study yesterday in Antimicrobial Resistance and Infection Control determined that multidrug-resistant A baumannii (MDR-Ab) infections in a Beirut hospital from 2007 through 2014 mostly consisted of ventilator-associated pneumonia and killed up to two thirds of patients.The researchers conducted a case-control study after MDR-Ab cases more than doubled at the American University of Beirut Medical Center ICU in 2007. That study involved patients diagnosed as having MDR-Ab in 2007 and 2008. The team also conducted a prospective study of MDR-Ab spread in the ICU in 2007 through 2014. The studies included 128 cases collectively and 99 patients who had MDR-Ab colonization but no evidence of active infection.The vast majority—84%—of cases were deemed hospital acquired, and 53% were ventilator-associated pneumonia. Mortality rates ranged from 52% to 66%. The investigators listed a range because “it was difficult to calculate the attributable mortality due to the fact that many patients were critically ill with multiple comorbid conditions.”The authors concluded, “Infection control measures should be reinforced to control the transmission of these organisms in the ICU.”Jan 22 Antimicrob Resist Infect Control study C diff prevention initiative helps reduce rates in VA facilitiesOriginally published by CIDRAP News Jan 22A significant decrease in rates of clinically confirmed long-term care facility onset CDI at 132 Veteran’s Affairs facilities coincided with implementation of a nationwide prevention initiative, researchers report in a new study in Infection Control and Hospital Epidemiology.The initiative for prevention of CDI in VA long-term care facilities (LTCFs) was implemented in February 2014 following implementation in VA acute care facilities in July 2012. The initiative, which emphasizes environmental management, hand hygiene, contact precautions, and institutional culture change, was extended and tailored to VA LTCFs because they are often linked to VA acute care facilities, where CDI has become the most common healthcare-associated infection. To evaluate the impact of the initiative, the researchers analyzed quarterly CDI trends from the first 33 months of the program and compared them with the 2 years prior to implementation.The analysis found that there were 137,289 admissions, 9,288,098 resident days, and 1,373 clinically confirmed LTCF-onset CDI cases from April 2014 through December 2016. The nationwide number of clinically confirmed LTCF-onset CDI cases did not change in the 2 years prior to implementation of the prevention initiative but decreased by 36.1% over the 33-month analysis period.The results mirror the experience in VA acute care facilities, which saw a 15% drop in hospital-acquired CDI cases over the first 33 months of the prevention initiative, and the authors note that this may have had an impact on their findings, along with strong leadership from the VA Central Office and individual facility accountability. “The exact reason for the decrease in cases within the VA LTCFs is not known,” they write. “Given the large number of facilities involved and the long observation period, we were not able to collect data on individual facility activities or sustainability of activities; hence, we cannot report a ‘magic bullet’ responsible for the declining trend.”Jan 21 Infect Control Hosp Epidemiol abstract Study shows substantial burden of primary, recurrent C diffOriginally published by CIDRAP News Jan 22In another study on CDI, researchers with Merck’s Center for Observational and Real World Evidence estimated the healthcare resource utilization (HCRU) and costs attributable to primary CDI and recurrent CDI (rCDI).In the retrospective observational study, published in Clinical Infectious Diseases, the researchers analyzed administrative claims data from two commercial databases representing nearly 50 million individuals with private health insurance. To obtain hospitalized days and costs attributable to primary CDI, patients without CDI were matched 1:1 by propensity score to those with primary CDI but no recurrences. To obtain hospitalized days and costs associated with rCDI, patients with primary CDI but no recurrences were matched 1:1 to those with primary CDI plus one recurrence.A total of 55,504 CDI patients were identified from July 2010 through June 2014, and among those patients 24.8% had a recurrence. Compared to those patients without CDI, the cumulative hospitalized days and healthcare costs attributable to primary CDI were 5.20 days and $24,205. Compared to those patients with primary CDI only, the cumulative hospitalized days and healthcare costs attributable to rCDI were 1.95 days and $10,580.”In conclusion, the HCRU and economic burden associated with primary and rCDI are quite substantial,” the authors write. “Better prevention and treatment of CDI, especially rCDI, are needed.”Jan 19 Clin Infect Dis study
Ryan Black (Photo by Ron Besser) CHARLOTTE, N.C. – In the final regular season tournament of 2009, the No. 17 West Florida men’s golf team tied for sixth place at the Palisades Collegiate Classic hosted by Charlotte on Tuesday. Sophomore Kyle Scott (Edenvale, South Africa/Edenglen HS) led the way, finishing seven under par and tied for fourth place overall.Scott was seven under after the first day, and he finished the third and final round at even part to finish at 209 (68-69-72). Freshman Ryan Black (Port St. Lucie, Fla./Lincoln Park Academy) posted the top final round with a 71 to finish tied for 10th (74-67-71=212).Freshman Rafael Rodriguez Larreta (Montevideo, Uruguay/Pocitos Day School) tied for 53rd (72-76-79=227) and freshman Carlos Rodriguez (Cali, Colombia/Austin Peay/Pendleton School) tied for 67th (75-78-78=231). Sophomore Otto Bonning (Skanor, Sweden/Sundsgymnasiet) had his best round on Tuesday, carding a 75 to finish tied for 70th (80-77-75=232).Virginia Commonwealth held on to take the team title, shooting 836 (282-270-284) to defeat Louisville by seven strokes (290-267-286=843). Marquette’s Mike Van Sickle claimed medalist honors at 16 under par (69-65-66=200).The Argonauts will head to the Gulf South Conference Championships next week on April 20-21, looking for their 10th GSC title and fourth in a row. For information on all UWF Athletics, visit www.GoArgos.com.#ARGOS#FINAL RESULTS1 VCU 282 270 284 836 -282 Louisville, U. of 290 267 286 843 -213 Marquette University 283 284 291 858 -64 Old Dominion Univ. 294 278 296 868 +45 Belmont Abbey Coll. 292 285 296 873 +9T6 West Florida, U. of 289 289 296 874 +10T6 Francis Marion U. 293 291 290 874 +10T8 Charlotte 296 291 290 877 +13T8 Longwood University 296 295 286 877 +1310 Richmond, Univ. of 301 286 299 886 +2211 Kennesaw St. Univ. 298 292 298 888 +2412 Davidson College 296 296 301 893 +2913 Winthrop University 307 296 292 895 +3114 Nebraska, U. of 298 301 298 897 +3315 Elon University 298 306 295 899 +35T4 Kyle Scott 68 69 72 209 -7T10 Ryan Black 74 67 71 212 -4T53 Rafael Rodriguez Larreta 72 76 79 227 +11T67 Carlos Rodriguez 75 78 78 231 +15T70 Otto Bonning 80 77 75 232 +16Print Friendly Version Share No. 17 UWF Finishes Regular Season at Palisades Classic
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By Helena Adeloju Police and Cardinia Life have paid tribute to a colleague and friend after Pakenham Upper resident Sergeant…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
The fixtures for the new league of Ireland season have been unveiled this afternoon. Fri. 13 April Galway United v Wexford Eamonn Deacy Park 7.45 pmFri. 20 April Shelbourne v Galway United Tolka Park 7.45 pmFri. 27 April Galway United v Cobh Ramblers Eamonn Deacy Park 7.45 pmFri. 4 May Athlone Town v Galway United Athlone Town Stadium 7.45 pmMONDAY/TUESDAY, 7/8 MAY – EA SPORTS CUP QUARTER-FINALS Fri. 11 May Galway United v U.C.D. Eamonn Deacy Park 7.45 pmFri. 18 May Cabinteely v Galway United Stradbrook 7.45 pmFri. 25 May Galway United v Drogheda United Eamonn Deacy Park 7.45 pmSat. 2 June Longford Town v Galway United City Calling Stadium 7.30 pmFri. 8 June Galway United v Finn Harps Eamonn Deacy Park 7.45 pmFri. 15 June Wexford v Galway United Ferrycarrig Park 8.00 pmMID-SEASON BREAK – SATURDAY 16 JUNE – THURSDAY 28 JUNE – NO FIXTURESFri. 29 June Galway United v Shelbourne Eamonn Deacy Park 7.45 pmFri. 6 July Galway United v Athlone Town Eamonn Deacy Park 7.45 pmSat. 14 July Cobh Ramblers v Galway United St. Colman’s Park 7.45 pmFri. 20 July U.C.D. v Galway United The UCD Bowl 7.45 pmFri. 27 July Galway United v Cabinteely Eamonn Deacy Park 7.45 pmFri. 3 August Drogheda United v Galway United United Park 7.45 pmFri. 3 August Shelbourne v Cobh Ramblers Tolka Park 7.45 pmFri. 3 August U.C.D. v Cabinteely The UCD Bowl 7.45 pmFri. 3 August Finn Harps v Wexford Finn Park 8.00 pmSat. 4 August Longford Town v Athlone Town City Calling Stadium 7.30 pmMONDAY 5 AUGUST – EA SPORTS CUP SEMI-FINALSWEEKEND ENDING SUNDAY 12 AUGUST – IRISH DAILY MAIL FAI CUP FIRST ROUNDFri. 17 August Galway United v Longford Town Eamonn Deacy Park 7.45 pmWEEKEND ENDING SUNDAY 26 AUGUST – IRISH DAILY MAIL FAI CUP SECOND ROUNDFri. 31 August Finn Harps v Galway United Finn Park 8.00 pmWEEKEND ENDING SUNDAY 9 SEPTEMBER – IRISH DAILY MAIL FAI CUP QUARTER-FINALSFri. 14 September Galway United v Wexford Eamonn Deacy Park 7.45 pmSATURDAY 15 SEPTEMBER – EA SPORTS CUP FINAL Sat. 22 September Shelbourne v Galway United Tolka Park 7.45 pmWEEKEND ENDING SUNDAY 30 SEPTEMBER – IRISH DAILY MAIL FAI CUP SEMI-FINALSFIRST DIVISION PROMOTION/RELEGATION PLAY-OFF SERIESFri. 5 October 4th placed First Division club v 3rd placed First Division clubMon. 8 October 3rd placed First Division club v 4th placed First Division clubFri. 12 October Winner of 4th v 3rd Play-off v 2nd placed First Division clubFri. 19 October 2nd placed First Division club v Winner of 4th v 3rd Play-offPROMOTION/RELEGATION PLAY-OFF FINALMon. 29 October Winner of First Division Play-off series v 9th placed Premier Division clubFri. 2 November 9th placed Premier Division club v Winner of First Division Play-off series(Or Wed. 7 November if one or both of the Clubs qualify for the Irish Daily Mail FAI Cup Final)SUNDAY 4 NOVEMBER – IRISH DAILY MAIL FAI CUP FINAL – AVIVA STADIUM Galway United will be at home for their first game of the season on Friday the 23rd of February when Athlone Town will visit Eamon Deacy Park followed by two away games to Cobh Ramblers and UCD. print WhatsApp Facebook Twitter Email Fri. 30 March Galway United v Longford Town Eamonn Deacy Park 7.45 pmMONDAY 2 APRIL – EA SPORTS CUP SECOND ROUND Fri. 6 April Finn Harps v Galway United Finn Park 8.00 pm United’s Fixtures in Full are….Fri. 23 February Galway United v Athlone Town Eamonn Deacy Park 7.45 pmSat. 3 March Cobh Ramblers v Galway United St. Colman’s Park 7.45 pmMONDAY 5 MARCH – EA SPORTS CUP FIRST ROUND Fri. 9 March U.C.D. v Galway United The UCD Bowl 7.45 pmFri. 16 March Galway United v Cabinteely Eamonn Deacy Park 7.45 pmFri. 23 March Drogheda United v Galway United United Park 7.45 pm
print WhatsApp Facebook Twitter Email The CCCC have confirmed the details of the Allianz National Hurling League Quarter Finals. Galway’s Quarter Final with Wexford will be played as a doubleheader with the Allianz National Football League clash of Galway and Roscommon in Pearse Stadium on Saturday next. The Hurling Quarter Final between Galway and Wexford will throw in at 1.30 with the Football throwing in at 3.30. All three Hurling Quarter Finals will be played on Saturday with Waterford and Clare in Walsh Park at 3pm and Tipperary and Dublin in Semple Stadium at 4.30. The Division One A Relegation Play-off between Kilkenny and Cork will be played at Nowlan Park and will throw in at 2pm.