First U.S.-based group to edit human embryos brings practice closer to clinic

first_imgPostfertilization editing Healthyegg Egg’sDNA An earlier edit Introducing CRISPR machinery at the point of fertilization appeared to eliminate patchy genome repair known as mosaicism. Mutated sperm and CRISPR introduced The ethical and practical debates over using the DNA-editing method CRISPR to alter human embryos just got less hypothetical. A week after the news leaked out, a U.S.-based team has published the first rigorous demonstration that CRISPR can efficiently repair a gene defect in human embryos—one that would cause a potentially deadly heart condition—without introducing new mutations elsewhere. Although none of the labmade embryos were transferred into women, the research team, led by embryologist Shoukhrat Mitalipov of Oregon Health and Science University (OHSU) in Portland, says the success paves the way for using the technique in the clinic to prevent the transmission of genetic disease.Because their approach appears to avoid the problems of patchy and imprecise editing seen in previous CRISPR tests on human embryos, the researchers claim it’s a viable strategy for rescuing mutated embryos that would otherwise be screened out of in vitro fertilization (IVF) procedures. But evidence of the technique’s long-term safety is still lacking, and many researchers and ethicists have argued that germline editing—making permanent, heritable changes to the genome that could correct genetic disease, but also theoretically introduce other designer traits—should for now be limited to research exploring basic biology.“I’m uncomfortable, honestly, with the sort of stated purpose of this study,” says Jennifer Doudna, a molecular biologist at the University of California, Berkeley, who is among the pioneers of the CRISPR method. “It’s not about research, I don’t think. It’s about how we get to a clinical application of this technology.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Mitalipov’s lab has navigated ethically complicated embryo research before. He advanced a technique to prevent the transmission of disease-causing mutations in a woman’s mitochondria, organelles with their own genes, by transferring her nuclear DNA into a donor egg, which is controversial because any offspring would inherit DNA from three individuals.But the CRISPR editing project was especially hard to sell to his university, Mitalipov says. He first made the proposal to OHSU’s institutional review board about 3 years ago. His plan was to use CRISPR—a DNA-cutting enzyme and an RNA that guides it to a target sequence—to slice into the gene MYBPC3 at the site of a mutation that leads to an enlarged heart and can cause sudden cardiac arrest, even in young, seemingly healthy athletes. The researchers would also insert short DNA strands bearing the healthy gene sequence. Then they would rely on a human embryo’s natural ability to repair cuts in its DNA, hoping it would use the healthy sequence as a template.The university set up two committees to judge the proposal, one evaluating its ethics and the other its scientific merits. Some of their members—kept anonymous even from Mitalipov—were hesitant to sign off, he says. The three other published human embryo–editing experiments, all from Chinese research teams using small numbers of embryos, have suggested that CRISPR’s enzyme sometimes cuts unintended targets in the DNA. They also produced embryos that were mosaic: A portion of their cells contained the healthy gene, whereas others kept the mutated one. Committee members thus worried the technique was too inefficient and risky to improve on current IVF procedures, Mitalipov recalls.Others questioned whether CRISPR technology was needed at all. A person carrying a mutated copy of the MYBPC3 gene still has a 50% chance of passing on the other, healthy copy, and doctors can already screen out mutated embryos during IVF. (People with two mutated copies of the gene are more rare, and their condition is more severe.) Mitalipov pushed back against reluctant committee members with his own take. “Discarding 50% of embryos [in IVF], knowing that you could actually correct the mutation, is morally wrong,” he told them.Because the work required creating and destroying human embryos, it was barred from receiving U.S. government funding. The OHSU lab used institutional funds; collaborators at the Salk Institute for Biological Studies in San Diego, California, relied on funding from three charitable foundations; Korean and Chinese collaborators also got federal or regional funding to help with the project.The OHSU group collected eggs from healthy women recruited and compensated for the research, and sperm from a man whom the OHSU’s cardiovascular institute had identified as having one mutated copy of MYBPC3. Instead of injecting the CRISPR system hours after the egg is fertilized, as in previous published experiments, they added it right alongside the sperm, hoping to prevent mosaicism by catching the new embryo before it had a chance to divide and make copies of the mutated gene. And to reduce the chance of cuts at unintended parts of the genome, they relied on a short-lived version of CRISPR, whose enzyme and guide RNA wouldn’t stick around in the cell after making their initial edit. G. Grullón/Science SpermDNAVariationsin repairCRISPR added as DNA replicatesMosaicembryo Human embryos, newly fertilized (left) and at the eight-cell stage (right), that had DNA edited by CRISPR. Sperm withmutation By Kelly ServickAug. 2, 2017 , 1:00 PMcenter_img Simultaneous injectionCRISPR First U.S.-based group to edit human embryos brings practice closer to clinic Egg’sDNA Nucleus Corrected sperm DNA HealthyeggUniformhealthy embryo Shoukhrat Mitalipov Of 58 IVF embryos that developed after the CRISPR injection, nearly three-quarters managed to repair the paternal MYBPC3. None of these successfully edited embryos harbored cells with the mutated gene, the researchers reported this week in Nature. And they found no evidence that CRISPR had cut outside the intended site.Unexpectedly, all but one of the embryos repaired the sliced MYBPC3 using the existing healthy copy of the gene (inherited from the egg donor), instead of the added template. Compared with more developed cells, maybe the early embryo “evolved to more efficiently repair errors in the DNA,” says Jun Wu, a stem cell biologist at Salk and a collaborator on the project. (Mitalipov cautions, however, that the repair process at work in these embryos is unlikely to be efficient if an embryo inherits mutated versions of a disease-causing gene from both parents. In such cases, researchers would need a more effective DNA template, Mitalipov says.)“This paper seems to allay many of the concerns about risk,” says George Daley, a stem cell researcher at Boston Children’s Hospital and dean of Harvard Medical School in Boston, “but it’s really, really important not to overinterpret and generalize.” Efficiency and the risk of off-target editing can vary based on the targeted gene, he notes.To some clinicians, even a slight increase in the healthy IVF embryo pool for certain couples seems justification enough for turning to CRISPR. Even if half of the embryos don’t inherit a mutated gene, those with the healthy gene may bear other abnormalities in older parents, and finding a viable one through screening can be difficult, says James Grifo, a reproductive endocrinologist at New York University’s Langone Medical Center in New York City. “I don’t think we should be alarmist about these possibilities of treating and avoiding disease.”But earlier this year, a committee convened by the U.S. National Academy of Sciences and the National Academy of Medicine in Washington, D.C., took a different position: that clinical use of germline editing could be allowed, but only in situations where a couple otherwise has no chance of a healthy biological child. In the new study, “we already have a case that challenges [those] criteria,” says Jeffrey Kahn, a bioethicist at Johns Hopkins University in Baltimore, Maryland, and a member of the panel. “As these kinds of research findings accumulate … at what point will somebody say it’s time to use this in a clinical context?”Mitalipov shares the concern that embryo editing will be used in the clinic before it’s fully understood. Congress prohibits the U.S. Food and Drug Administration from approving clinical trials involving embryo editing. But despite a similar restriction on the mitochondrial method Mitalipov pioneered, a U.S. fertility specialist used it last fall to produce an apparently healthy baby in Mexico. As Mitalipov’s team continues to optimize the gene-editing technique for a possible clinical trial, “we’re not going to transfer [embryos to a uterus] without oversight,” he says. But, he adds, “the private clinics will be using it one way or another.”last_img read more

RSS’ mission Northeast on campus: Sangh reaches out to GenNext

first_imgWhile the BJP scripted a historic performance last week in the Northeast elections, sources say much of the credit goes to its ideological mentor Rashtriya Swayamsevak Sangh (RSS) for its outreach programme aimed at lakhs of students from the region across the country.Buoyed by the massive expansion of the Sangh in the northeastern states that essentially won the BJP youth support, the RSS will further intensify its spread in campuses and hostels in every nook and corner particularly in educational hubs such as Delhi, Bengaluru, Mumbai, and Pune.In the run-up to the assembly polls in Tripura, Nagaland, and Meghalaya, the RSS mobilised its cadre to visit campuses and hostels to connect to north-eastern students.A large number of first-time voters in the three states were associated with the ideology that helped the BJP gain a strong foothold in these states. In Tripura, there were 47,000 first-time voters while in Meghalaya and Nagaland, this number stood at 45,000 and 26,000.Sunil Deodhar, RSS Tripura in-charge since 2014, said during the last three years the Sangh launched massive student outreach programmes.We visited hostels in major cities and connected to the northeastern students. The youth easily connected to the issues of resentment over unemployment, crime, and crumbling infrastructure. This helped us create a new BJP structure in the Northeast to take on the Left rule, Deodhar said after BJPs landmark show.PROMOTING IDEOLOGY Another functionary of RSS said a number of educational and sports programmes were rolled out for tribal youths. Many of them were sent to various events held outside the state.advertisementIn January, the RSS organised a mass contact and expansion programme in Assam which was named Lui Poria (sons of Brahmaputra). While the focus area was Assam, people from villages and cities from all the eight northeastern states joined it.With the political fight in Karnataka scheduled for April-May, the RSS will target colleges and educational institutions in the state. Bengaluru has a large population of northeastern students whom the Sangh is seeking to associate with its ideology.It may be noted that in 2012, a large number of northeastern students had to flee the city after hate attacks. Sources say even then RSS workers stood in support of the community and urged them to stay back.Similarly, with the admission session soon to start in Delhi University, RSS student wing Akhil Bharatiya Vidyarthi Parishad (ABVP) will reach out to northeastern students in every part of the national Capital. The idea is to instill a sense of integration and social security among the Northeastern communities who often face discrimination and are subject to attacks.The Sangh will also rope in youths from states such as Tripura, Nagaland, Manipur, and Meghalaya to connect the students in bigger cities with its ideology. These northeastern youth will share their experience of association with the Sangh and its agenda of nationalism.At the same time, they will narrate their story of change in the state to northeastern students living away from their homes. Senior functionaries of RSS told Mail Today that a number of Sangh wings and affiliated organisations are closely involved with the expansion programme.In northeastern states, organisations such as Ekal Vidyalaya, Vanvasi Kalyan Ashram, Rashtra Sevika Samiti and Vivekananda Kendra reached out to tribal youths and the exercise gained momentum during the last three years. Deodhars experience of teaching in schools also came as an advantage as he connected to the students.The Sangh believes in one nation, one culture. Connecting northeastern communities with the mainstream and bridging the communication gap has been the prime objective of the RSS and its affiliates. Students Experience in Inter-state Living (SEIL) is one such initiative by the ABVP which has yielded positive results, said Rajiv Tuli, RSS Delhis Prachar Pramukh.He said SEIL aims to forge a sense of belongingness and self-realisation of cultural similarities among the youth with a more practical approach towards national integration.Through Yuva Vikas Kendra and other organisations, efforts are being made to bring together divergent lifestyles particularly of our border area people and other parts of the nation. The idea is to establish a cultural rapport and to provide opportunities to the youth of the country to experience art and culture of the northeastern region, Tuli said.Also watch – Sunil Deodhar, architect of BJP’s win, reveals how party took Tripura from Leftlast_img read more

Ajay Devgn to play football coach Syed Abdul Rahim in Boney Kapoor’s next

first_imgAjay Devgn is on a roll. After signing Neeraj Pandey’s Chanakya, the 49-year-old actor will now be seen in another biopic. This time he has bagged Boney Kapoor’s production in which he is set to essay the role of legendary football coach Syed Abdul Rahim.At a time when sports biopics have become a rage with Bollywood, Ajay Devgn has decided to bring the story of an unsung hero on the big screen with Boney’s untitled film.Directed by Amit Sharma, the film will tell the journey of Syed Abdul Rahim, under whose leadership, Indian football team won the Asian games in 1951 and 1962.Talking about the film, Boney Kapoor told a leading daily, “I was amazed that not many are aware of someone as significant as Syed Abdul Rahim. He’s an unsung hero whose achievements must be saluted. His team had heroes like Chunni Goswami, PK Banerjee, Balaram, Franco and Arun Ghosh. It takes someone like Ajay Devgn to play Syed Abdul Rahim. With him on board, I can just hope that our film inspires youngsters to play football, and India soon to bring the World Cup home.”Elated and proud to announce a story never told as @ZeeStudios_ #BoneyKapoor & @freshlimefilms come together for a biopic on Indias legendary #Football coach, Syed Abdul Rahim, starring @ajaydevgn, directed by @CinemaPuraDesi, screenplay by @SaiwynQ, and dialogues by @writish. Studios (@ZeeStudios_) July 13, 2018Apart from this, Ajay Devgn has Luv Ranjan’s untitled film with Ranbir Kapoor and Total Dhamaal in his kitty.advertisementALSO READ | Ajay Devgn to play Chanakya in Neeraj Pandey’s filmALSO READ | Did you know Ajay Devgn has been in jail twice?ALSO WATCH: I can take on anybody with my little finger, says Ajay Devgnlast_img read more

Four-goal Liverpool rout Bournemouth

first_imgBournemouth 0 Liverpool 4: Coutinho sparkles as Reds return to winning ways Tom Webber Last updated 1 year ago 02:23 12/18/17 Liverpool - cropped Getty Images Philippe Coutinho reached double figures for goals for the third straight season with his effort in Liverpool’s win at Bournemouth. Philippe Coutinho was in dazzling form as Liverpool got back to winning ways with an impressive 4-0 victory over Bournemouth at the Vitality Stadium on Sunday.A scintillating solo strike and an assist from Coutinho lifted Jurgen Klopp’s side back up to fourth after successive draws against Everton and West Brom saw the gap to the top three widen.Coutinho started wide on the left as Sadio Mane was granted a rest under the rotation policy for which Klopp has come under fire and the Brazilian quickly set about ensuring the scrutiny of his manager would be minimal with a fine individual goal. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player Klopp this week lauded Liverpool’s scouting department for their role in the signing of Mohamed Salah from Roma and they may be expecting further praise after the winger added to Dejan Lovren’s header by slotting his 20th goal of 2017-18 home before half-time.Simon Mignolet – back between the posts in place of Loris Karius – had little to contend with in the Liverpool goal and the visitors were out of sight when Roberto Firmino nodded Coutinho’s cross home in the second half, though replays suggested he may have been offside.Salah, Firmino and Coutinho all made way in the second half as, with victory on the south coast secure, Klopp turned his attention to a huge clash with fellow Champions League chasers Arsenal at Emirates Stadium on Friday.FULL-TIME Bournemouth 0-4 LiverpoolIrresistible. Unstoppable.Coutinho, Lovren, Salah & Firmino fire @LFC back into the top four #BOULIV— Premier League (@premierleague) December 17, 2017With less than 11 minutes played, Nathan Ake was booked for tugging Firmino down on the edge of the box and Coutinho saw a sweetly struck free-kick hit the inside of the right-hand upright and bounce away from goal.The Brazilian was not to be denied at the next attempt, though. Coutinho dribbled at speed down the left, cut inside Simon Francis and slotted a fine effort inside the near post after beating Lewis Cook.Liverpool added a second six minutes later when Firmino stopped the ball crossing the byline by hooking it into the six-yard box on the volley for Lovren to finish with a diving header.Klopp’s energetic side had been dominant but eased off before half-time and Bournemouth – who lost Josh King to injury in the 31st minute – would have punished them had Jermain Defoe’s 39th-minute effort not come back off the post.Asmir Begovic denied Alex Oxlade-Chamberlain and Salah as Liverpool responded positively, and the Reds enhanced their advantage when the Egyptian raced down the outside of Charlie Daniels on the right before shifting the ball onto his left foot and picking out the far corner.20 – Mohamed Salah is the first @premierleague player to have scored 20 goals in all competitions this season. Prolific.— OptaJoe (@OptaJoe) December 17, 2017Liverpool struggled to maintain their intensity after the restart and it was not until Oxlade-Chamberlain dispossessed former Red Jordon Ibe and surged into the box only to hit the upright with a powerful left-footed strike that they threatened again.Defoe was unable to get the better of Mignolet from the edge of the area and Liverpool had maximum points secured when Firmino ghosted into space between two Bournemouth defenders to head Coutinho’s delivery home.Klopp sent Adam Lallana on in place of Salah for just his second appearance of an injury-plagued season with under 20 minutes remaining.Danny Ings then hit the side-netting and Lallana looped a stoppage-time header over after Begovic kept out Dominic Solanke, but Liverpool had done enough to extend their unbeaten run in all competitions to 12 matches.Key Opta stats:- Liverpool are the first team in top-flight history to have won four consecutive away games by a margin of at least three goals.- Mo Salah became the first Premier League player to reach 20 goals in all competitions this season. He’s also the first Liverpool player since Luis Suarez (31) and Daniel Sturridge (24) in 2013-14 to score at least 20 goals in a single campaign.- Roberto Firmino has been involved in more Premier League goals than any other Liverpool player since he joined at the start of 2015-16 (44, 27 goals, 17 assists).- Philippe Coutinho has been directly involved in 15 goals in his last 10 away games for Liverpool in all competitions (8 goals, 7 assists).- No team has scored more away goals in the Premier League this season than Liverpool (24, level with Manchester City). read morelast_img read more

10 months agoBarcelona ace Dembele scoffs at claims of paying pal €15,000-a-month

first_imgBarcelona ace Dembele scoffs at claims of paying pal €15,000-a-monthby Carlos Volcano10 months agoSend to a friendShare the loveBarcelona ace Ousmane Dembele has scoffed at claims he is paying a friend to make sure he does things on time.Dembele continues to upset management and senior players with his poor timekeeping.And Radio Marca reported that Dembele is paying one of his entourage €15,000-a-month to keep him on the straight and narrow.However, Dembele has denied the story with a reaction on Twitter with several disparaging emojis.— Ousmane Dembélé (@Dembouz) December 19, 2018 About the authorCarlos VolcanoShare the loveHave your saylast_img read more

Jim Harbaugh Comments On Michigan Player’s Pregame Midfield Incident

first_imgMichigan head coach Jim Harbaugh patting a player on the head.ANN ARBOR, MI – SEPTEMBER 22: Head coach Jim Harbaugh celebrates a first half score with Shea Patterson #2 while playing the Nebraska Cornhuskers on September 22, 2018 at Michigan Stadium in Ann Arbor, Michigan. (Photo by Gregory Shamus/Getty Images)The Michigan Wolverines picked up another statement victory over the weekend, but it didn’t come without controversy. Before they defeated the Michigan State Spartans on the road, Jim Harbaugh’s players found themselves making headlines for all the wrong reasons.During warmups, linebacker Devin Bush unleashed his hatred for Michigan State by scraping the Spartan logo. It’s possible that his emotions got caught up in the rivalry, yet it was still unsettling to watch.After two days since the situation occurred, Harbaugh has finally opened up about the situation.“I don’t blame Devin. I liked the way our guys handled it. That would be like going back and saying, “Oh, look at Devin Bush, look at him out there. He’s out at midfield scraping up the logo.” After what just took place, that’s straight out of the Pistons’ playbook. Do something to them, say something to them, elbow them and when somebody else does something back, then flop.”Harbaugh on Devin Bush and scraping the Spartan logo— angelique (@chengelis) October 22, 2018Regardless of everyone else’s opinion on the topic, Michigan’s head coach isn’t furious with Bush’s pre-game antics.It probably wasn’t the wisest decision in the world, but at least his actions weren’t harmful.Harbaugh normally sides with players, and once again he’s proving that he won’t throw his guys under the bus. Perhaps, that is the reason behind Michigan’s success of late.last_img read more

MacKay may order review of search and rescue protocol after teens death

first_imgAPTN National NewsDefence Minister Peter MacKay says a review may be on the horizon on how ground search crews communicate with the military.MacKay was once again defending the armed forces and its role in the search for Burton Winters, 14.MacKay, at a news conference Monday in Halifax, responded to more questions about the military’s role in searching for the teen who was found dead after a four day search about 20 kilometres from his community of Makkovik, Labrador.There are still questions over why the military search and rescue helicopter didn’t arrive on the scene sooner.MacKay says the military followed its set of guidelines.last_img read more

Trans Mountain pipeline wont cause tension with Notley at meeting Horgan

first_imgFinance Minister Bill Morneau said Wednesday the federal government is prepared to offer an “indemnity” to help ease the political risks for any investors to ensure the pipeline expansion can proceed.(THE CANADIAN PRESS) Plans to triple capacity along Kinder Morgan’s existing Trans Mountain pipeline from Edmonton to Burnaby have pitted Alberta and the federal government against B.C.’s government, which says it fears the impact a spill would have on the province’s environment and economy.“I believe, largely, the issue is around transporting diluted bitumen, whether it is by rail or by pipeline,” said Horgan. “I believe the risk of a diluted bitumen spill to our environment, to our economy, is too great. I’ve made that abundantly clear. I don’t think there’ll be any surprises next week.”B.C. filed a reference case in the province’s Court of Appeal last month to determine if it has jurisdiction to regulate heavy oil shipments. It also joined two other lawsuits launched by Indigenous groups opposed to the $7.4-billion project.Kinder Morgan has ceased all non-essential spending on the project until it receives assurances it can proceed without delays, setting a May 31 deadline on getting those guarantees. “The federal government now wants to talk about a national program,” Horgan said. “We’re excited about that, but we don’t want to be pushed aside after all the work we’ve done here in B.C. at the provincial level and to have the federal government come in and tell us where and how and what we should be doing.”He said B.C. wants to ensure the provinces continue to play a leading role in the development of pharmacare.Horgan said he and Notley only disagree on the Trans Mountain project, otherwise, their views “are lockstep.”On Thursday, B.C. announced plans to launch a lawsuit over new Alberta legislation that could restrict fuel exports to the West Coast.B.C. Attorney General David Eby said his province will ask the Court of Queen’s Bench in Alberta to declare the legislation unconstitutional on the grounds that one province cannot punish another.Notley said Thursday that Alberta is confident it has the authority to control the export of its own resources and she believes the new law will withstand a legal challenge, adding her province must safeguard its interests.center_img LANGFORD, B.C. – The premiers of British Columbia and Alberta will join their counterparts from Western Canada and the North at meetings next week in Yellowknife, but John Horgan doesn’t expect any drama over the Trans Mountain pipeline expansion project.Horgan acknowledges he and Alberta’s Rachel Notley have differences on the pipeline, but he said Friday they are in agreement on a number of other matters and have been friends for 20 years.The ongoing tensions over the Trans Mountain project should not spill over into the expected major focus of the gathering, which is the development of a national pharmacare program, Horgan said. The provinces have always led the way on cost savings for prescription drugs and B.C. wants to be at the forefront of the issue, he added.last_img read more

Marrakech International Film Festival to Take Place from November 29 to

Rabat – The Marrakech Film Festival Foundation has confirmed that the iconic event will take place this year from November 29 to December 7. The festival program and guests of honour are yet to be announced.The festival was launched in 2001 by the King of Morocco to promote the country’s cinema industry and has since grown to be one of the most famous film festivals in the world. A number of different venues across Marrakech draw thousands of attendees every year, who come to see a selection of films from across the world. Over 100 000 people attended the screenings in 2018. Stars and industry figures also come to be seen walking the glamorous red carpet, to the delight of fashion magazines. Read also: Toronto Hot Docs Film Festival to Premiere Moroccan Amazigh Amussu FilmLast year, the festival honored American actress Robin Wright and French director Agnes Varda, along with the iconic, Robert De Niro.This year’s festival will include the annual competition, where films are awarded a variety of prizes by a jury of industry professionals, the press release says. In addition to the official competition, the festival will again include the “Conversation With” initiative, where professionals and the general public are able to meet some of the great names in the world of cinema, the release adds.The press release does not reveal further details on the stars expected to be attending the event.Last year’s interactive talk series hosted Martin Scorsese, Guillermo Del Toro, and Agnes Varda, among other world-famous stars. The sessions each attracted close to 500 people, including film industry professionals, journalists, students, and film lovers more broadly. read more

SecretaryGeneral recommends sixmonth extension of UN Interim Force in Lebanon

In a new report to the Security Council, Mr. Annan says the situation along the Blue Line, except in the sector adjacent to the Shab´a farms area, remained generally calm. “Most of the violations of the line were minor and quickly corrected once UNIFIL had raised them with the party concerned,” he notes. At the same time, the report cites recent events involving exchanges of fire which wounded Israeli, Lebanese and Syrian soldiers as evidence that the dangerous situation is potentially threatening to the stability of the region. The Secretary-General stresses that it is of “paramount importance that all parties concerned respect the Blue Line as called for by the Security Council, cease all violations thereof and desist from any action that could serve to destabilize the situation.” Attacks across the line in the Shab’a farms area were the greatest cause of concern, while the persistent Israeli violations of Lebanese airspace have created additional tension, according to the report. “A pledge on 28 June by the Israeli Minister of Defence to my representatives in the region, Terje Roed-Larsen and Staffan de Mistura, to stop at least the flights over cities deep inside Lebanon, has yet to be fulfilled,” the Secretary-General notes. The report also mentions the controversy that arose over a videotape made by UN peacekeepers of vehicles that might have been used in the abduction of three Israeli soldiers last October, and notes that Israel and Lebanon have been offered the opportunity to view the tape, with the identities of non-UN personnel obscured.Under-Secretary-General for Management Joseph Connor, who has been charged with leading an investigation into the internal handling of the matter, is at UNIFIL headquarters in Naqoura today, according to a UN spokesman. “He is meeting with UNIFIL staff as part of his investigation, which he hopes to wrap up by the end of the month,” spokesman Fred Eckhard told reporters in New York.The Security Council is expected to hold consultations on Lebanon on Wednesday. read more

UN Population Fund expands work on reproductive health worldwide

The father of the nine-year-old Kenyan girl, Silvia, married her off to the mature man as his fourth wife without consulting her mother. As the child was being frog-marched to his house after the Maasai wedding, the UNFPA-funded Tasaru Ntomonok (“Rescue the Woman”) Girls Rescue Centre intervened. The groom escaped, but Silvia’s father was jailed for one year.Phyllis, a 16-year-old Kenyan girl, took refuge at the centre after her police officer father tried to force her to undergo female genital mutilation/cutting (FGM/C), a rite of passage outlawed in Kenya since 2001. Her father threatened the police officers protecting her and to take her mother’s life if she dared to visit her. He later refused to pay for the education of her six younger siblings.The centre has instituted an alternative rite of passage, at which older women, skilled in the traditions, give the girls the same information on reproductive health, sexuality and the challenges of adulthood, such as how to handle their home and husband, but without cutting.In Chad and southern Indonesia, UNFPA has faced the challenge of making childbirth safer for women.In Chad, prolonged labour used to give young mothers the hole between vagina and bladder or rectum, called fistulas, leading to incontinence and worse. UNFPA spearheaded a campaign performing fistula repair and subsequently helped the affected mothers get caesarean deliveries.In southern Indonesia, the national initiative is called the Mother Friendly Movement and it has trained midwives for tens of thousands of villages and given grants for emergency transport to hospitals when the problems go beyond what midwifery can handle.Meanwhile, at the Las Palmas Air Force Base in Lima, Peru, Air Force Captain Monica Gonzáles Méder is coaching first-year students in how to express happiness, sadness – and tenderness. The exercise is meant to improve the cadets’ self-esteem, help them get in touch with and control their emotions and be more responsible in their sexual relationships.In 1992, the Government created the Peruvian Armed Forces and Police Committee for the Prevention of HIV/AIDS, known by its Spanish acronym, COPRECOS. Under the leadership of its first president, Juan Alva, an air force general and medical doctor, COPRECOS helped create counterparts in 11 Latin American and Caribbean countries. Peru has since been playing a leading role in Latin America and the Caribbean in protecting military and police recruits from HIV.Since 2000, UNFPA, the United Nations Population Fund, has helped strengthen COPRECOS. It has trained 341 teachers in topics relating to reproductive and sexual health, as well as the prevention of HIV and other sexually transmitted infections and is helping to prevent HIV among military and police personnel in more than a dozen countries in Latin America and the Caribbean.“Police officers must often fill the roles of teacher, parent, social communicator and psychologist, so it’s important for us to have this knowledge, both for our personal and professional lives,” says Jorge Romero Wiracocha, a second-year student at the Peruvian police school. read more

Disney raises theme park ticket prices

Disney raises theme park ticket prices by News Staff Posted Feb 23, 2015 7:26 am MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email A trip to the Magic Kingdom is going to cost more.Walt Disney is raising theme park ticket prices after investing billions in the parks for new attractions.Disney has raised the cost of a single-day admission to its flagship Magic Kingdom park in Orlando to $105 US, breaking the $100 level for the first time.Prices for the company’s three other Orlando resorts will rise three per cent to $97, and $99 at Disneyland in California.The company has invested more than $8-billion in the past five years in its U.S. parks, opening new attractions and doubling the size of the Magic Kingdom’s Fantasyland section.The cost of admission to the Magic Kingdom has doubled since 2003.Disney’s domestic park attendance climbed three per cent in the fiscal year according to company filings.The parks division generated operating income of almost $2.7 billion on revenue of $15.1 billion in 2014.Disney ticket-price increases often lead to similar moves by other operators such as Comcast Corp.’s Universal Studios and SeaWorld Entertainment Inc. locations. read more

Over 40 teams apply for 4th Koper Handball Cup – Dont wait FACEBOOK PAGE ← Previous Story Hungary win Olympic Hopes U17 Tournament in Prague Next Story → HBC Nantes smash PSG Handball in front of 11.000 fans The 4th Koper Handball Cup 2017 will be held between April 14 and 16 in beautiful atmosphere of Slovenian coast in city of Koper, the famous one for it’s handball club Cimos Koper, which played a few years ago at VELUX EHF Champions League 1/4 finals.Tournament set a new record of 92 teams in edition 2016, but organizers announced expectations that 110 teams will compete in 2017! For now, over 40 teams from Croatia, Italy, Austria, Slovakia, Slovenia and Germany applied for the tournament.As every year, Koper Handball Cup working on some improvements and providing new ideas. All the guests of Slovenian seaside will have a chance to see demonstration of handball in wheelchairs, but also coaching seminar with topic “Inovations in handball” on which all the coaches can participate and sent their suggestions.kopercup@gmail.com limited number of teams on 10 per category, so hurry up to find your place!Categories: 2007 ( mini ), 2006 ( mini ), 2005, 2004, 2003, 2002, 2000, 1997. Koper Handball Cup read more

Gardaí given extra €55 million to help fight threat of international terrorism

first_imgWe are very careful in the alertness of our security forces – gardaí and defence forces – who make every effort possible to see that people are protected and that lives are protected in that regard.Read: Dublin Fire Brigade to be balloted on industrial action >Read: Australian firm responsible for Irishwoman’s scalping injuries fined > Image: Eamonn Farrell/ Sunday 15 Jan 2017, 7:10 AM 10,195 Views Short URL By Garreth MacNamee The level of threat from this source is kept under constant review by An Garda Síochána, particularly in the light of ongoing developments and the current international situation.“I secured additional funding of €55 million which included additional sums specifically to support the force’s capabilities and actions to counter international terrorism, including equipment and training.”Fitzgerald also said there is concern about a number of people who have sympathies with international terror groups. understands that these people are being monitored by a number of different garda intelliegenec units and all information is being shared with the relevant organisations.She added: “While there are a number of persons here whose activities in support of extremism give rise to concern they will continue to be monitored closely by the garda authorities and all appropriate measures will be taken in this regard.” The money is being allocated for additional resources. Source: Eamonn Farrell/RollingNews.ieLast month, Taoiseach Enda Kenny said gardaí and defence forces are doing everything in their power to prevent an attack in Ireland similar to the recent attack in Berlin.Twelve people were killed when a 40-tonne lorry, driven by a Tunisian asylum seeker, rammed through a crowded Christmas market.Kenny told reporters he hopes “nothing like that would happen here”. However, he said “these things can happen”.“You can ever rule anything out, but we like to think that in this country people are vigilant that we’re careful and that we’ll do everything we can to protect our citizens,” he said. 69 Comments Jan 15th 2017, 7:10 AM Share Tweet Email AN ADDITIONAL €55 million has been allocated to specifically address the threat of international terrorism.Justice Minister Frances Fitzgerald said that the money will be used so specialist garda units can receive the training required. The money would also be used to procure more equipment.Fitzgerald said that Ireland is “not immune” to the threat of terrorism but that an attack was “unlikely”.She said: “The current assessment of the threat is that while an international terrorist attack on Ireland is possible, it is not considered likely. Nor is there at present any specific information that an attack on Ireland is planned. Gardaí given extra €55 million to help fight threat of international terrorism Justice Minister Frances Fitzgerald says Ireland “is not immune” from the threat of terrorism. Image: Eamonn Farrell/ Tweet thisShare on FacebookEmail this articlelast_img read more